Augmentation of Aortic Ring Contractions by Angiotensin II Antisense Peptide
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چکیده
منابع مشابه
Augmentation of aortic ring contractions by angiotensin II antisense peptide.
Previous biochemical experiments have revealed two antisense peptide antagonists to human angiotensin II (Ang II), one encoded in the cDNA in the antiparallel reading, the other in the parallel reading. Neither peptide's ability to produce physiological antagonism has been demonstrated previously. Both peptides were tested for their ability to antagonize Ang II-induced contractions on rabbit ao...
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In several models of angiotensin II (ANG II) dependent hypertension, intrarenal ANG II levels increase to a much greater extent than the circulating levels even though the renal renin levels are decreased. The 2-kidney-1-clip (2K1C) Goldblatt rat model is particularly intriguing because hypertension develops in the presence of an intact kidney which would be expected to maintain sodium balance ...
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Rats infused chronically with Val(5)-Angiotensin (Ang) II exhibit increased urinary excretion of endogenous Ile(5)-Ang II by the 12th day of infusion, suggesting the stimulation of endogenous Ang II formation by Val(5)-Ang II infusion. The present study determined the time course of increased urinary Ang II excretion and the effects of Ang II type 1 receptor blockade (candesartan, 2 mg/kg per d...
متن کاملAngiotensin II Type 1 Receptor–Mediated Augmentation of Urinary Excretion of Endogenous Angiotensin II in Val-Angiotensin II–Infused Rats
Rats infused chronically with Val-Angiotensin (Ang) II exhibit increased urinary excretion of endogenous Ile-Ang II by the 12th day of infusion, suggesting the stimulation of endogenous Ang II formation by Val-Ang II infusion. The present study determined the time course of increased urinary Ang II excretion and the effects of Ang II type 1 receptor blockade (candesartan, 2 mg/kg per day) on th...
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The objectives of this study were to determine the effects of chronic angiotensin II (ANG II) infusions on ANG II content and angiotensinogen expression in the mouse kidney and the role of the angiotensin II type 1 receptor (AT(1)R) in mediating these changes. C57BL/6J male mice were subjected to ANG II infusions at doses of 400 or 1,000 ng.kg(-1).min(-1) either alone or with an AT(1)R blocker ...
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ژورنال
عنوان ژورنال: Hypertension
سال: 1998
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.31.3.854